Double - Negative ( CD 4 - CD 8 - ) T Cells From Adult T - ce l l Leukemia Patients Also Have Poor

نویسندگان

  • Hitoshi Suzushima
  • Norio Asou
  • Shintaro Nishimura
  • Kouji Nishikawa
  • Jian-xiang Wang
  • Toshiya Okubo
  • Makoto Naito
  • Toshio Hattori
  • Kiyoshi Takatsuki
چکیده

We present four patients with adult T-cell leukemia (ATL) derived from a novel T-cell subset (CD4-, CD8[doublenegative, DN], T-cell receptor [TCR] &). In the ATL cells of these patients, neither gene nor surface expression of CD4 and CD8 antigens was detected. Clinical and laboratory data showed no difference between DN-ATL and CD4+ATL patients. In contrast to typical CD4+ATL cells, DN-ATL cells were shown to express the protein and messenger RNA (mRNA) for S1 OO@ in immunocytochemical assay and the reverse-transcription polymerase chain reaction assay. The mean fluorescence intensity of the TCR/ CD3 complex was extremely low in all four DN-ATL patients as well as in typical CD4+ ATL. All four patients had TCR

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تاریخ انتشار 2003